Applicants must be graduating or have graduated from a Canadian Council for Accreditation of Pharmacy Programs-accredited faculty of pharmacy or otherwise be eligible for licensure in a Canadian province. Applicants participating in the CPRB residency matching service must abide by the policies and rules of the matching service. Registration with the CPRB Pharmacy Residency Application Matching Service (PRAMS) is a requirement for application to accredited programs outside Québec.

Programs may have different policies with regard to eligibility requirements and entrance criteria. The CPRB encourages applicants to investigate the requirements of the programs they are interested in applying to, and reminds applicants that eligibility for the PRAMS process does not necessarily entail eligibility for every residency program featured in PRAMS.